Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible to the cellular machinery that works to express the right genes at the ...

Scientists reveal a hidden second layer of human DNA, showing how genome folding controls genes and influences disease development.

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team. DNA is widely accepted to be formed of two strands that wind around one ...

Scientists have uncovered a surprising secret about our DNA: it’s not a static blueprint, but a constantly shifting, folding ...

CRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human health care in the last decade. It is a ...

Fox Chase researchers use 3D genomic testing to improve lymphoma and sarcoma diagnosis and treatment by revealing tumor cell ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Researchers at Aarhus University have developed a microscopic DNA needle that can deliver molecules directly into cells—and, ...

The period between the 1920s and 1950s was a time of significant progress and exciting discoveries in gene therapy history and biomedicine. Groundbreaking advances in understanding inherited DNA and ...